8,13-dihydroindolo(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, rutaecarpine, rutecarpine
| Name | Rutaecarpine | ||
| PubChem CID | 65752 | ||
| Molecular Weight | 287.3g/mol | ||
| Synonyms |
8,13-dihydroindolo(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, rutaecarpine, rutecarpine |
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| Formula | C₁₈H₁₃N₃O | ||
| SMILES | C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4 | ||
| InChI | 1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2 | ||
| InChIKey | ACVGWSKVRYFWRP-UHFFFAOYSA-N | ||
| CAS Number | 84-26-4 | ||
| ChEMBL ID | CHEMBL85139 | ||
| ChEBI ID | CHEBI:8922 | ||
| Herb ID | HBIN042657 | ||
| KEGG ID | C09238 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ShiHu | ||
| Use Part | Stem | ||
| Habitat | GuangXi, GuiZhou, YunNan, HuBei | ||
| Flavor | Sweet | ||
| Meridian Tropism | Stomach, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Orchidaceae
-->Genus: Dendrobium
-->Species: Dendrobium nobile
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| Chineses Pinyin | GuanHuangBai | ||
| Use Part | Bark | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, ShanDong, JiangSu, ZheJiang | ||
| Flavor | Bitter | ||
| Meridian Tropism | Kidney, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Phellodendron
-->Species: Phellodendron amurense
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| Chineses Pinyin | WuZhuYu | ||
| Use Part | Fruit | ||
| Habitat | GuangDong, GuangXi, HaiNan, Hongkong , Shaanxi, GuiZhou, HuNan, YunNan, ZheJiang, SiChuan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Spleen, Stomach, Kidney | ||
| Chineses Pinyin | ChouCao | ||
| Use Part | Whole Herb | ||
| Habitat | China | ||
| Flavor | Pungent, Mildly bitter | ||
| Meridian Tropism | Lung, Kidney, Liver, Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Ruta
-->Species: Ruta graveolens
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| Pair Name | Rutaecarpine, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Down-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Expression | CDK4 | hsa1019 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 | |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| In Vivo Model | Each mouse was subcutaneously injected with 1×10⁶ of an HCT cell suspension near the right axilla and the tumor size and weight of each mouse were measured every other day. | |||
| Result | Combined therapy with 5-FU and RUT exerted a superior curative effect in CRC than treatment with either single drug alone and has potential as a novel therapeutic modality for the treatment of CRC. | |||
