Pair Name	Paeoniflorin, Talatizidine
Disease Info	[ICD-11: FA20]	Rheumatoid arthritis		Investigative
Biological Phenomena	Induction-->Adipogenesis and lipogenesis
Gene Regulation	Up-regulation	Expression	ALOX15B	hsa247
	Down-regulation	Expression	JUN	hsa3725
	Up-regulation	Expression	MMP13	hsa4322
	Up-regulation	Expression	PPARG	hsa5468
	Down-regulation	Expression	TGFB1	hsa7040
In Vivo Model	Male Lewis rats were injected intradermally at the base of the tail with 10 mg/mL M tuberculosis H37 Ra suspended in liquid paraffin.
Result	This study identified PAE and TLT as the main BACs of WTD in alleviating the severity of RA, and also developed a novel combination of PAE and TLT as a promising candidate drug for RA therapy.