| Name | Polyunsaturated fatty acid lipoxygenase ALOX15B | ||
| UniProt ID | LX15B_HUMAN | ||
| Gene Name | ALOX15B | ||
| Gene ID | 247 | ||
| Synonyms |
ALOX15B, 15-LOX-2
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| Sequence |
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL PYTYLDPPLIENSVSI |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa247 | ||
| Pfam | PF00305; PF01477; PF12168 | ||
| Pair Name | Paeoniflorin, Talatizidine | |||
| Phytochemical | Paeoniflorin | |||
| Drug | Talatizidine | |||
| Disease Info | [ICD-11: FA20] | Rheumatoid arthritis | Investigative | |
| Regulate Info | Up-regulation | Polyunsaturated fatty acid lipoxygenase ALOX15B | Expression | |
| Result | This study identified PAE and TLT as the main BACs of WTD in alleviating the severity of RA, and also developed a novel combination of PAE and TLT as a promising candidate drug for RA therapy. | |||
