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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Oridonin, Fluorouracil
Phytochemical Name Oridonin (PubChem CID: 5321010 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 181
Ref_1
Pair Name Oridonin, Fluorouracil
Disease Info [ICD-11: 2C90.Z] Renal carcinoma Investigative
Biological Phenomena Induction-->Necroptosis
Gene Regulation Up-regulation Activity MAPK1 hsa5594
Up-regulation Activity MAPK14 hsa1432
Up-regulation Activity MAPK8 hsa5599
In Vitro Model 786-O Renal cell carcinoma Homo sapiens (Human) CVCL_1051
In Vivo Model 786-O cells (1×10⁶) were subcutaneously injected into the right flank.
Result Oridonin enhances the cytotoxicity of 5-FU in renal cancer cells partially through inducing necroptosis, providing evidence of using necroptosis inducers in combination with chemotherapeutic agents for cancer treatment.
03. Reference
No. Title Href
1 Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death. Biomed Pharmacother. 2018 Oct;106:175-182. doi: 10.1016/j.biopha.2018.06.111. Click
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