| Name | Menadione | ||
| PubChem CID | 4055 | ||
| Molecular Weight | 172.18g/mol | ||
| Synonyms |
2-Methyl-1,4-naphthalenedione, 2-Methyl-1,4-naphthoquinone, 2-Methylnaphthoquinone, Bisulfite, Menadione, Bisulfite, Menadione Sodium, Menadione, Menadione bisulfite, Menadione sodium bisulfite, Menadione sodium bisulfite, trihydrate, Sodium Bisulfite, Menadione, Vicasol, Vikasol, Vitamin K 3, Vitamin K3, Vitamin K3 sodium bisulfite |
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| Formula | C₁₁H₈O₂ | ||
| SMILES | CC1=CC(=O)C2=CC=CC=C2C1=O | ||
| InChI | 1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3 | ||
| InChIKey | MJVAVZPDRWSRRC-UHFFFAOYSA-N | ||
| CAS Number | 58-27-5 | ||
| ChEMBL ID | CHEMBL590 | ||
| ChEBI ID | CHEBI:28869 | ||
| Herb ID | HBIN034731 | ||
| Drug Bank ID | DB00170 | ||
| KEGG ID | C05377 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | TieJiaoJue | ||
| Use Part | Whole herb or leaf | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Polypodiales
-->Family: Aspleniaceae
-->Genus: Asplenium
-->Species: Asplenium trichomanes
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| Pair Name | Menadione, Ascorbic Acid | |||
| Partner Name | Ascorbic Acid | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| Gene Regulation | Down-regulation | Expression | BECN1 | hsa8678 |
| Up-regulation | Activity | BECN1 | hsa8678 | |
| Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
| Down-regulation | Expression | RHEB | hsa6009 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| Up-regulation | Phosphorylation | ULK1 | hsa8408 | |
| In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
| Result | These results suggest that AA+MD or MD treatment in combination with autophagy inducers could be further investigated as a novel approach for glioblastoma therapy. | |||
| Pair Name | Menadione, Sodium orthovanadate | |||
| Partner Name | Sodium orthovanadate | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| In Vitro Model | DBTRG-05MG | Anaplastic astrocytoma | Homo sapiens (Human) | CVCL_1169 |
| Result | Our results indicate that M:SO combination is an attractive alternative for glioma treatment that encourages further study. The neutralizing effects of genistein and DTT reveal a possibility for their use in the minimization of potential M:SO systemic toxicity. | |||
| Pair Name | Menadione, Sodium orthovanadate | |||
| Partner Name | Sodium orthovanadate | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | Our data guarantee further studies to evaluate the in vivo occurrence of D-IDCs, their implications for invasiveness and metastasis and their sensitivity to anticancer drugs. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells. Oxid Med Cell Longev. 2022 Mar 23;2022:2998132. doi: 10.1155/2022/2998132. | Click |
| 2 | Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells. Invest New Drugs. 2012 Aug;30(4):1302-10. doi: 10.1007/s10637-011-9680-y. | Click |
| 3 | Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells. ISRN Pharmacol. 2012;2012:307102. doi: 10.5402/2012/307102. | Click |
