| Pair Name | Mahanine, Fluorouracil | ||
| Phytochemical Name | Mahanine (PubChem CID: 36689305 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Fluorouracil |
| Adverse Reactions | Application site erythema, application site pruritus. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Pueraria thomsonii; Bupleurum scorzonerifolium; Pueraria thomsonii; Pueraria edulis |
| Reference | Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019. ref_link |
| Pair Name | Mahanine, Fluorouracil | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Down-regulation | Expression | TP73 | hsa7161 | |
| Up-regulation | Phosphorylation | PTEN | hsa5728 | |
| Down-regulation | Phosphorylation | MDM2 | hsa4193 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. Apoptosis. 2024 Feb 28. doi: 10.1007/s10495-024-01951-8. | Click |
