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isocorydine, isocorydine hydrochloride, (S)-isomer, isocorydine, (R)-isomer, isocorydine, (S)-isomer

No.	Title	Href
1	Isocorydine decrease gemcitabine-resistance by inhibiting epithelial-mesenchymal transition via STAT3 in pancreatic cancer cells. Am J Transl Res. 2020 Jul 15;12(7):3702-3714.	`Click`

No.

Title

Href

Isocorydine decrease gemcitabine-resistance by inhibiting epithelial-mesenchymal transition via STAT3 in pancreatic cancer cells. Am J Transl Res. 2020 Jul 15;12(7):3702-3714.

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Name	Isocorydine
PubChem CID	10143
Molecular Weight	341.4g/mol
Synonyms	isocorydine, isocorydine hydrochloride, (S)-isomer, isocorydine, (R)-isomer, isocorydine, (S)-isomer
Formula	C₂₀H₂₃NO₄
SMILES	CN1CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)OC)OC
InChI	1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InChIKey	QELDJEKNFOQJOY-ZDUSSCGKSA-N
CAS Number	475-67-2
ChEMBL ID	CHEMBL489525
ChEBI ID	CHEBI:6000
Herb ID	HBIN030604
KEGG ID	C09549
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BaiYaoZi
Use Part	Tuberoid
Habitat	JiangSu, AnHui, ZheJiang, JiangXi, FuJian, TaiWan, HuNan, GuangDong, GuangXi, GuiZhou
Flavor	Bitter, Pungent
Meridian Tropism	Lung, Stomach

Chineses Pinyin	BaiQuCai
Use Part	Whole Herb
Habitat	HeiLongJiang, JiLin, LiaoNing, JiangSu, ShanDong
Flavor	Bitter
Meridian Tropism	Lung, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Papaveraceae 　　　　　-->Genus: Chelidonium 　　　　　　-->Species: Chelidonium majus

Chineses Pinyin	YanHuSuo
Use Part	Tuberoid
Habitat	HeBei, ShanDong, JiangSu, ZheJiang
Flavor	Pungent, Bitter
Meridian Tropism	Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Papaveraceae 　　　　　-->Genus: Corydalis 　　　　　　-->Species: Corydalis yanhusuo

Chineses Pinyin	AoXianZiJin
Use Part	Whole Herb
Habitat	HeNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, ShanXi, GanSu
Flavor	Bitter, Astringent
Meridian Tropism	Lung, Kidney, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Papaveraceae 　　　　　-->Genus: Corydalis 　　　　　　-->Species: Corydalis edulis

Chineses Pinyin	ChengQieZi
Use Part	Fruit
Habitat	GuangXi, ZheJiang, SiChuan, FuJian
Flavor	Pungent, Mildly bitter
Meridian Tropism	Stomach, Spleen, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Laurales 　　　　-->Family: Lauraceae 　　　　　-->Genus: Litsea 　　　　　　-->Species: Litsea cubeba

Chineses Pinyin	DianBanYingSu
Use Part	Seed
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Papaveraceae 　　　　　-->Genus: Papaver 　　　　　　-->Species: Papaver commutatum

Chineses Pinyin	NanTianZhuGeng
Use Part	Branchlet
Habitat	Shaanxi, JiangSu, ZheJiang, AnHui, JiangXi, FuJian, HuBei, GuangDong, GuangXi, YunNan, SiChuan, GuiZhou
Flavor	Pungent, Bitter
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Berberidaceae 　　　　　-->Genus: Nandina 　　　　　　-->Species: Nandina domestica

Chineses Pinyin	ZhiXieMuPi
Use Part	Bark
Habitat	GuangDong, HaiNan, GuangXi, YunNan
Flavor	Bitter
Meridian Tropism	Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Gentianales 　　　　-->Family: Apocynaceae 　　　　　-->Genus: Holarrhena 　　　　　　-->Species: Holarrhena pubescens

Chineses Pinyin	TuChuangHua
Use Part	Whole herb
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Papaveraceae 　　　　　-->Genus: Dicranostigma 　　　　　　-->Species: Dicranostigma leptopodum

Pair Name	Isocorydine, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Expression	TWIST1	hsa7291
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	CFPAC-1	Cystic fibrosis	Homo sapiens (Human)	CVCL_1119
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
	PaTu 8988t	Pancreatic adenocarcinoma	Homo sapiens (Human)	CVCL_1847
In Vivo Model	1×10⁷ PANC-1 cells were suspended in 100 μL of phosphate-buffered saline (PBS) and implanted subcutaneously into the right flank of each nude mouse.
Result	The synergistic treatment effect of the combination treatment of ICD and gemcitabine in pancreatic cancer cells was confirmed in established xenograft models.