| Pair Name | Honokiol, Oxaliplatin | ||
| Phytochemical Name | Honokiol (PubChem CID: 72303 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Honokiol, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Expression | MAPK3 | hsa5595 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| Result | This combination allows a reduction in oxaliplatin dose, and thereby reduces its adverse effects. It may also enhance the chemotherapeutic effect of oxaliplatin for this disease. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells. Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):773-9. doi: 10.1093/abbs/gmt071. | Click |
