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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Falcarindiol
PubChem CID 5281148
Molecular Weight 260.4g/mol
Synonyms

falcalindiol, falcarindiol, heptadeca-1,9-diene-4,6-diyne-3,8-diol
Formula C₁₇H₂₄O₂
SMILES CCCCCCCC=CC(C#CC#CC(C=C)O)O
InChI 1S/C17H24O2/c1-3-5-6-7-8-9-10-14-17(19)15-12-11-13-16(18)4-2/h4,10,14,16-19H,2-3,5-9H2,1H3/b14-10-/t16-,17+/m1/s1
InChIKey QWCNQXNAFCBLLV-YWALDVPYSA-N
CAS Number 55297-87-5
ChEMBL ID CHEMBL69018
Herb ID HBIN026343
KEGG ID C08449
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Carpesium abrotanoides Even
Chineses Pinyin HeShi
Use Part Fruit
Habitat HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, HeNan, Shaanxi, GanSu
Flavor Bitter, Pungent
Meridian Tropism Spleen, Stomach
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asterales
　　　　-->Family: Asteraceae
　　　　　-->Genus: Carpesium
　　　　　　-->Species: Carpesium abrotanoides
(2) Angelica dahurica Warm
Chineses Pinyin BaiZhi
Use Part Root
Habitat HeBei, HeNan, ShanXi, NeiMengGu, Shaanxi
Flavor Pungent
Meridian Tropism Stomach, Large intestine, Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Angelica
　　　　　　-->Species: Angelica dahurica
(3) Glehnia littoralis Cold
Chineses Pinyin BeiShaShen
Use Part Root
Habitat LiaoNing, HeBei, ShanDong
Flavor Sweet, Mildly bitter
Meridian Tropism Lung, Stomach
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Glehnia
　　　　　　-->Species: Glehnia littoralis
(4) Ligusticum chuam Warm
Chineses Pinyin ChuanXiong
Use Part Rhizome
Habitat SiChuan
Flavor Pungent
Meridian Tropism Liver, Gallbladder, Pericardium
(5) Angelica sinensis Warm
Chineses Pinyin DangGui
Use Part Root
Habitat SiChuan, YunNan, Shaanxi, GuiZhou, QingHai, NingXia
Flavor Sweet, Pungent
Meridian Tropism Liver, Heart, Spleen
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Angelica
　　　　　　-->Species: Angelica sinensis
(6) Angelica pubescens Warm
Chineses Pinyin DuHuo
Use Part Root
Habitat HuBei, SiChuan, JiangXi
Flavor Pungent, Bitter
Meridian Tropism Kidney, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Angelica
　　　　　　-->Species: Angelica pubescens
(7) Saposhnikovia divaricata Warm
Chineses Pinyin FangFeng
Use Part Root
Habitat HeiLongJiang, JiLin, LiaoNing, NeiMengGu
Flavor Pungent, Sweet
Meridian Tropism Bladder, Liver, Spleen
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Saposhnikovia
　　　　　　-->Species: Saposhnikovia divaricata
(8) Daucus carota Even
Chineses Pinyin NanHeShi
Use Part Fruit
Habitat JiangSu, HeNan, HuBei, ZheJiang
Flavor Bitter, Pungent
Meridian Tropism Spleen, Stomach
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Daucus
　　　　　　-->Species: Daucus carota
(9) Kitagawia praeruptora Cold
Chineses Pinyin QianHu
Use Part Root
Habitat ZheJiang, HuNan, SiChuan
Flavor Bitter, Pungent
Meridian Tropism Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Kitagawia
　　　　　　-->Species: Kitagawia praeruptora
(10) Hansenia weberbaueriana Warm
Chineses Pinyin QiangHuo
Use Part Rhizome, Root
Habitat SiChuan, GanSu, QingHai
Flavor Pungent, Bitter
Meridian Tropism Bladder, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Hansenia
　　　　　　-->Species: Hansenia weberbaueriana
(11) Ferula sinkiangensis Warm
Chineses Pinyin ChouAWei
Use Part Balsam
Habitat XinJiang
Flavor Bitter, Pungent
Meridian Tropism Spleen, Stomach
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Ferula
　　　　　　-->Species: Ferula sinkiangensis
(12) Hansenia forbesii Warm
Chineses Pinyin KuanYeQiangHuo
Use Part Rhizome, Root
Habitat ShanXi, Shaanxi, HuBei, SiChuan, NeiMengGu, GanSu, QingHai
Flavor Bitter, Pungent
Meridian Tropism Bladder, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Hansenia
　　　　　　-->Species: Hansenia forbesii
(13) Kitagawia praeruptora Cold
Chineses Pinyin LiJiangQianHu
Flavor Bitter, Pungent
Meridian Tropism Lung, Spleen, Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Kitagawia
　　　　　　-->Species: Kitagawia praeruptora
(14) Aralia fargesii Warm
Chineses Pinyin LongYanDuHuo
Use Part Rhizome, Root
Habitat YunNan
Flavor Bitter, Pungent
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Araliaceae
　　　　　-->Genus: Aralia
　　　　　　-->Species: Aralia fargesii
(15) Seseli yunnanensis Even
Chineses Pinyin SongYeFangFeng
Use Part Root
Habitat SiChuan, GuiZhou, YunNan, XiZang, ChongQing, GuangXi
Flavor Pungent
(16) Daucus carota Even
Chineses Pinyin YeHuLuoBo
Use Part Root, Fruit
Habitat SiChuan, GuiZhou, HuBei, JiangXi, AnHui, JiangSu
Flavor Bitter, Pungent
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Daucus
　　　　　　-->Species: Daucus carota
(17) Glehnia littoralis Cold
Chineses Pinyin ShanHuCai
Habitat LiaoNing, HeBei, ShanDong
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Apiales
　　　　-->Family: Apiaceae
　　　　　-->Genus: Glehnia
　　　　　　-->Species: Glehnia littoralis
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 577
Ref_1
Pair Name Falcarindiol, Cisplatin
Partner Name Cisplatin
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression RAD51 hsa5888
Down-regulation Expression BRCA1 hsa672
Down-regulation Expression MDC1 hsa9656
Down-regulation Phosphorylation STAT3 hsa6774
Down-regulation Expression PTTG1 hsa9232
In Vitro Model Huh-7 Adult hepatocellular carcinoma Homo sapiens (Human) CVCL_0336
LM3 Malignant neoplasms of the mouse mammary gland Mus musculus (Mouse) CVCL_D269
Result Our study illustrated that FAD is a potential anticancer drug and strengthens the chemosensitivity of HCC cells to DDP by inhibiting the STAT3/PTTG1 pathway.
04. Reference
No. Title Href
1 Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway. Front Pharmacol. 2021 May 7;12:656697. doi: 10.3389/fphar.2021.656697. Click
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