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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Deoxyelephantopin, Cisplatin
Phytochemical Name Deoxyelephantopin (PubChem CID: 6325056 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cisplatin
Adverse Reactions Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug.
Recommendations Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 272
Ref_1
Pair Name Deoxyelephantopin, Cisplatin
Disease Info [ICD-11: 2C30] Melanoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Expression CCNA2 hsa890
Down-regulation Expression CCND1 hsa595
Down-regulation Expression CDK1 hsa983
Down-regulation Expression MMP9 hsa4318
Up-regulation Expression TP53 hsa7157
In Vitro Model B16 Mouse melanoma Mus musculus (Mouse) CVCL_F936
In Vivo Model The other six groups of mice were intravenously (i.v.) injected with 1×10⁵ B16 cells in 200 μl PBS through the tail vein at day 0.
Result The CP and DET combination may be an effective intervention for melanoma with reduced side effects.
03. Reference
No. Title Href
1 Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity. Phytomedicine. 2019 Mar 15;56:194-206. doi: 10.1016/j.phymed.2018.11.005. Click
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