Pair Name	Aloe emodin, Gefitinib
Partner Name	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	SLC22A3	hsa6581
In Vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_B260
	PC-9-GR-high	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_S706
In Vivo Model	After acclimated for one week, subcutaneous inoculation of 1×10⁷ PC9-GR cells was executed into the right flank of the animals (n = 4 in each group) to develop xenograft models.
Result	AE could enhance the gefitinib sensitivity of PC9-GR cells and reverse EMT by blocking PI3K/Akt/TWIS1 signal pathway.

Pair Name	Aloe emodin, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Down-regulation	Activity	ABCB1	hsa5243
	Up-regulation	Cleavage	CASP3	hsa836
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Our study indicated that AE could be a potential reversal agent to resensitize ADR resistant in tumor chemotherapy and inhibiting autophagy might be an effective strategy to further enhance the reversal activity of AE.

Pair Name	Aloe emodin, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	MGMT	hsa4255
	Down-regulation	Expression	NFKB1	hsa4790
In Vitro Model	IRCC-Neuromed-NULU	Glioblastoma	Homo sapiens (Human)	CVCL_B1D1
	IRCC-Neuromed-ZAR	Glioblastoma	Homo sapiens (Human)	CVCL_B1CY
Result	These convincing results suggest that AE could be a natural adjuvant agent to potentiate the effects of traditional drugs (TMZ) and overcome drug resistance in glioblastoma cells.