| Pair Name | Trifolirhizin, Sorafenib | ||
| Phytochemical Name | Trifolirhizin (PubChem CID: 442827 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Sorafenib |
| Adverse Reactions | Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium; |
| Reference | Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022. ref_link |
| Pair Name | Trifolirhizin, Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| In Vitro Model | MHCC97-H | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4972 |
| In Vivo Model | Each mouse was subcuta-neously inoculated in the right flank with 100μl PBS (PH 7.4) contain-ing 1.5×10⁶ HepG2 cells. | |||
| Result | Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma. Phytother Res. 2023 Feb;37(2):592-610. doi: 10.1002/ptr.7637. | Click |
