trifolirhizin
| Name | Trifolirhizin | ||
| PubChem CID | 442827 | ||
| Molecular Weight | 446.4g/mol | ||
| Synonyms |
trifolirhizin |
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| Formula | C₂₂H₂₂O₁₀ | ||
| SMILES | C1C2C(C3=C(O1)C=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O)OC5=CC6=C(C=C25)OCO6 | ||
| InChI | 1S/C22H22O10/c23-6-17-18(24)19(25)20(26)22(32-17)30-9-1-2-10-13(3-9)27-7-12-11-4-15-16(29-8-28-15)5-14(11)31-21(10)12/h1-5,12,17-26H,6-8H2/t12-,17+,18+,19-,20+,21-,22+/m0/s1 | ||
| InChIKey | VGSYCWGXBYZLLE-QEEQPWONSA-N | ||
| CAS Number | 6807-83-6 | ||
| ChEMBL ID | CHEMBL454878 | ||
| ChEBI ID | CHEBI:9714 | ||
| Herb ID | HBIN047035 | ||
| KEGG ID | C10538 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | KuShen | ||
| Use Part | Root | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver, Stomach, Large intestine, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
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| Pair Name | Trifolirhizin, Sorafenib | |||
| Partner Name | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| In Vitro Model | MHCC97-H | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_4972 |
| In Vivo Model | Each mouse was subcuta-neously inoculated in the right flank with 100μl PBS (PH 7.4) contain-ing 1.5×10⁶ HepG2 cells. | |||
| Result | Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma | |||
