| Pair Name | Sulforaphane, Selenium | ||
| Phytochemical Name | Sulforaphane (PubChem CID: 5350 ) | ||
| Anticancer drug Name | Selenium (PubChem CID: 6326970 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Sulforaphane, Selenium | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Protection oxidative damage | |||
| Gene Regulation | Up-regulation | Expression | NFE2L2 | hsa4780 |
| Up-regulation | Expression | TXNRD1 | hsa7296 | |
| In Vitro Model | CCD-841CoN | Healthy | Homo sapiens (Human) | CVCL_2871 |
| Result | Combined SFN and Se treatment synergistically upregulated TrxR-1, which plays a significant role in maintaining intracellular redox homeostasis and contributed to the SFN-induced protection against free radical-mediated oxidative damage in normal colonic cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells. Nutr Res. 2015 Jul;35(7):610-7. doi: 10.1016/j.nutres.2015.05.011. | Click |
