Pair Name	Sulforaphane, Acetazolamide
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Gene Regulation	Down-regulation	Expression	NANOGNB	hsa360030
	Down-regulation	Expression	POU5F1	hsa5460
	Down-regulation	Expression	SOX2	hsa6657
In Vitro Model	NCI-H727	Lung carcinoid tumor	Homo sapiens (Human)	CVCL_1584
	NCI-H720	Lung carcinoid tumor	Homo sapiens (Human)	CVCL_1583
In Vivo Model	H727 and H720 parental and 3rd generation spheroid cells (3×10⁴) were injected into the subcutaneous inguinal fat pad of NOD/SCID mice.
Result	Human bronchial carcinoid tumor cells serially passaged as spheroids contain a higher fraction of TIC exhibiting a stemness phenotype. This TIC population can be effectively targeted by the combination of AZ + SFN. Our work portends clinical relevance and supports the therapeutic use of the novel AZ+ SFN combination that may target the TIC population of bronchial carcinoids.