InterPAD - DETAILS

acetazolamide, 59-66-5, Diamox, Acetamox, Nephramide, Glaupax, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, Acetazolamid, Defiltran, Phonurit, Donmox, Edemox, Didoc, Diuriwas, Cidamex, Diacarb, Diluran, Dehydratin, Natrionex, Nephramid, Diakarb, Diuramid, Diutazol, Duiramid, Eumicton, Fonurit, Vetamox, Glupax, SK-acetazolamide, 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide, Acetazolamidum, Acetazoleamide, Acetozalamide, Diureticum-holzinger, Acetamidothiadiazolesulfonamide, Acetazolamida, Glaumox, Diamox Sequels, 4-Diamox, Atenezo, Carbonic Anhydrase Inhibitor No. 6063, 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide, Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-, 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole, Acetazolamidum [INN-Latin], N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide, Acetazolamida [INN-Spanish], CCRIS 5811, NSC 145177, HSDB 3002, 1,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-, Carbonic anhydrase inhibitor 6063, EINECS 200-440-5, UNII-O3FX965V0I, 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide, N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide, NSC-145177, O3FX965V0I, DTXSID7022544, CHEBI:27690, AI3-52458, Acetazolamide (Standard), CHEMBL20, MFCD00003105, Diamox (TN), Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-, MLS000028435, DTXCID002544, Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-, 5-acetylamino-1,3,4-thiadiazole-2-sulfonamide, Acetazolamide [USP:INN:BAN:JAN], L 579486, NSC145177, CAS-59-66-5, NCGC00015074-10, Acetazolamine, Atenezol, SMR000058394, Acetazolamidum (INN-Latin), Acetazolamida (INN-Spanish), ACETAZOLAMIDE (MART.), ACETAZOLAMIDE [MART.], ACETAZOLAMIDE (USP-RS), ACETAZOLAMIDE [USP-RS], N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide, N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide, ACETAZOLAMIDE (EP IMPURITY), ACETAZOLAMIDE [EP IMPURITY], Acetazolamide (USP:INN:BAN:JAN), ACETAZOLAMIDE (EP MONOGRAPH), ACETAZOLAMIDE [EP MONOGRAPH], ACETAZOLAMIDE (USP MONOGRAPH), ACETAZOLAMIDE [USP MONOGRAPH], Acetazolamide (AAZ), SR-01000000065, N-(5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl)acetamide, Prestwick_4, 1azm, 1yda, 1ydb, 1ydd, 1zsb, 2xtk, 3czv, 3ucj, Acetazolamide, 5, Acerazolamide, AAZ, Acetazolamide, AAZ, Acetazolamide, AZA, Acetazolamide, AZM, ACETAZIDE, ATENAZOL, Spectrum_000018, 1jd0, 2h4n, 2uy4, 3dc3, 3hs4, 3ml5, 4g0c, Opera_ID_288, AZA2, Prestwick0_000003, Prestwick1_000003, Prestwick2_000003, Prestwick3_000003, Spectrum2_000082, Spectrum3_000284, Spectrum4_000139, Spectrum5_000738, Lopac-A-6011, ACETAZOLAMIDE [MI], A 6011, ACETAZOLAMIDE [INN], ACETAZOLAMIDE [JAN], ACETAZOLAMIDE [HSDB], Lopac0_000039, SCHEMBL23219, ACETAZOLAMIDE [VANDF], BSPBio_000005, BSPBio_001788, KBioGR_000558, KBioSS_000358, MLS001148438, Acetazolamide Extended-Release, BIDD:GT0643, DivK1c_000017, SPECTRUM1500102, N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-acetamide, SPBio_000004, SPBio_001926, ACETAZOLAMIDE [WHO-DD], ACETAZOLAMIDE [WHO-IP], BPBio1_000007, GTPL6792, Acetazolamide, >=99%, powder, SCHEMBL11049053, BDBM10880, BZKPWHYZMXOIDC-UHFFFAOYSA-, HMS500A19, HY-B0782R, KBio1_000017, KBio2_000358, KBio2_002926, KBio2_005494, KBio3_001288, Acetazolamide (JP17/USP/INN), AMY3289, N-[5-(Aminosulfonyl)-1,3,4-thiadiozol-2-yl]-Acetamide, S01EC01, Acetazolamide, analytical standard, NINDS_000017, HMS1568A07, HMS1920A05, HMS2091G05, HMS2095A07, HMS2232G23, HMS3259I13, HMS3260G19, HMS3370P01, HMS3712A07, HMS3744A21, Pharmakon1600-01500102, WLN: T5NN DSJ CSZW EMV1, ACETAZOLAMIDE [ORANGE BOOK], ALBB-023617, BCP29616, HY-B0782, Tox21_110078, Tox21_201559, Tox21_302773, Tox21_500039, CCG-38900, NSC755854, s4506, ACETAZOLAMIDUM [WHO-IP LATIN], AKOS000715163, Tox21_110078_1, CS-3568, DB00819, LP00039, NC00491, NSC-755854, SDCCGSBI-0050028.P005, IDI1_000017, NCGC00015074-01, NCGC00015074-02, NCGC00015074-03, NCGC00015074-04, NCGC00015074-05, NCGC00015074-06, NCGC00015074-07, NCGC00015074-08, NCGC00015074-09, NCGC00015074-11, NCGC00015074-12, NCGC00015074-14, NCGC00015074-15, NCGC00015074-17, NCGC00015074-22, NCGC00023455-03, NCGC00023455-04, NCGC00023455-05, NCGC00023455-06, NCGC00023455-07, NCGC00256374-01, NCGC00259108-01, NCGC00260724-01, AC-12779, AS-13169, SBI-0050028.P004, 2-Acetamido-5-sulfonamido-1,4-thiadiazole, 5-Acetamide-1,4-thiadiazole-2-sulfonamide, DB-053437, 5-Acetamido-1,3,4-thiadiazol-2-sulfonamide, AB00051906, CS-0694998, EU-0100039, NS00008947, 1,4-Thiadiazole-2-sulfonamide, 5-acetamido-, CARBONIC ANHYDRASE INHIBITOR NO 6063, C06805, D00218, D88526, EN300-119493, AB00051906_15, A832415, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanamide, Q413690, Q-200579, Q-200580, SR-01000000065-2, SR-01000000065-4, SR-01000000065-6, 1,3,4-THIADIAZOLE-2-SULFONAMIDE, 5-ACETAMIDO, 2-ACETAMIDO-1,3,4-THIADIAZOLE-5-SULFONAMIDE, BRD-K43457670-001-22-9, BRD-K43457670-001-26-0, Z277559108, (1z)-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanimidic acid, Acetazolamide, European Pharmacopoeia (EP) Reference Standard, Acetazolamide, United States Pharmacopeia (USP) Reference Standard, Acetazolamide for system suitability, European Pharmacopoeia (EP) Reference Standard, Acetazolamide, Pharmaceutical Secondary Standard; Certified Reference Material, 124442-28-0, 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide;N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide;N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, InChI=1/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

Name	Acetazolamide
PubChem CID	1986
Molecular Weight	222.3g/mol
Synonyms	acetazolamide, 59-66-5, Diamox, Acetamox, Nephramide, Glaupax, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, Acetazolamid, Defiltran, Phonurit, Donmox, Edemox, Didoc, Diuriwas, Cidamex, Diacarb, Diluran, Dehydratin, Natrionex, Nephramid, Diakarb, Diuramid, Diutazol, Duiramid, Eumicton, Fonurit, Vetamox, Glupax, SK-acetazolamide, 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide, Acetazolamidum, Acetazoleamide, Acetozalamide, Diureticum-holzinger, Acetamidothiadiazolesulfonamide, Acetazolamida, Glaumox, Diamox Sequels, 4-Diamox, Atenezo, Carbonic Anhydrase Inhibitor No. 6063, 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide, Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-, 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole, Acetazolamidum [INN-Latin], N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide, Acetazolamida [INN-Spanish], CCRIS 5811, NSC 145177, HSDB 3002, 1,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-, Carbonic anhydrase inhibitor 6063, EINECS 200-440-5, UNII-O3FX965V0I, 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide, N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide, NSC-145177, O3FX965V0I, DTXSID7022544, CHEBI:27690, AI3-52458, Acetazolamide (Standard), CHEMBL20, MFCD00003105, Diamox (TN), Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-, MLS000028435, DTXCID002544, Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-, 5-acetylamino-1,3,4-thiadiazole-2-sulfonamide, Acetazolamide [USP:INN:BAN:JAN], L 579486, NSC145177, CAS-59-66-5, NCGC00015074-10, Acetazolamine, Atenezol, SMR000058394, Acetazolamidum (INN-Latin), Acetazolamida (INN-Spanish), ACETAZOLAMIDE (MART.), ACETAZOLAMIDE [MART.], ACETAZOLAMIDE (USP-RS), ACETAZOLAMIDE [USP-RS], N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide, N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide, ACETAZOLAMIDE (EP IMPURITY), ACETAZOLAMIDE [EP IMPURITY], Acetazolamide (USP:INN:BAN:JAN), ACETAZOLAMIDE (EP MONOGRAPH), ACETAZOLAMIDE [EP MONOGRAPH], ACETAZOLAMIDE (USP MONOGRAPH), ACETAZOLAMIDE [USP MONOGRAPH], Acetazolamide (AAZ), SR-01000000065, N-(5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl)acetamide, Prestwick_4, 1azm, 1yda, 1ydb, 1ydd, 1zsb, 2xtk, 3czv, 3ucj, Acetazolamide, 5, Acerazolamide, AAZ, Acetazolamide, AAZ, Acetazolamide, AZA, Acetazolamide, AZM, ACETAZIDE, ATENAZOL, Spectrum_000018, 1jd0, 2h4n, 2uy4, 3dc3, 3hs4, 3ml5, 4g0c, Opera_ID_288, AZA2, Prestwick0_000003, Prestwick1_000003, Prestwick2_000003, Prestwick3_000003, Spectrum2_000082, Spectrum3_000284, Spectrum4_000139, Spectrum5_000738, Lopac-A-6011, ACETAZOLAMIDE [MI], A 6011, ACETAZOLAMIDE [INN], ACETAZOLAMIDE [JAN], ACETAZOLAMIDE [HSDB], Lopac0_000039, SCHEMBL23219, ACETAZOLAMIDE [VANDF], BSPBio_000005, BSPBio_001788, KBioGR_000558, KBioSS_000358, MLS001148438, Acetazolamide Extended-Release, BIDD:GT0643, DivK1c_000017, SPECTRUM1500102, N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-acetamide, SPBio_000004, SPBio_001926, ACETAZOLAMIDE [WHO-DD], ACETAZOLAMIDE [WHO-IP], BPBio1_000007, GTPL6792, Acetazolamide, >=99%, powder, SCHEMBL11049053, BDBM10880, BZKPWHYZMXOIDC-UHFFFAOYSA-, HMS500A19, HY-B0782R, KBio1_000017, KBio2_000358, KBio2_002926, KBio2_005494, KBio3_001288, Acetazolamide (JP17/USP/INN), AMY3289, N-[5-(Aminosulfonyl)-1,3,4-thiadiozol-2-yl]-Acetamide, S01EC01, Acetazolamide, analytical standard, NINDS_000017, HMS1568A07, HMS1920A05, HMS2091G05, HMS2095A07, HMS2232G23, HMS3259I13, HMS3260G19, HMS3370P01, HMS3712A07, HMS3744A21, Pharmakon1600-01500102, WLN: T5NN DSJ CSZW EMV1, ACETAZOLAMIDE [ORANGE BOOK], ALBB-023617, BCP29616, HY-B0782, Tox21_110078, Tox21_201559, Tox21_302773, Tox21_500039, CCG-38900, NSC755854, s4506, ACETAZOLAMIDUM [WHO-IP LATIN], AKOS000715163, Tox21_110078_1, CS-3568, DB00819, LP00039, NC00491, NSC-755854, SDCCGSBI-0050028.P005, IDI1_000017, NCGC00015074-01, NCGC00015074-02, NCGC00015074-03, NCGC00015074-04, NCGC00015074-05, NCGC00015074-06, NCGC00015074-07, NCGC00015074-08, NCGC00015074-09, NCGC00015074-11, NCGC00015074-12, NCGC00015074-14, NCGC00015074-15, NCGC00015074-17, NCGC00015074-22, NCGC00023455-03, NCGC00023455-04, NCGC00023455-05, NCGC00023455-06, NCGC00023455-07, NCGC00256374-01, NCGC00259108-01, NCGC00260724-01, AC-12779, AS-13169, SBI-0050028.P004, 2-Acetamido-5-sulfonamido-1,4-thiadiazole, 5-Acetamide-1,4-thiadiazole-2-sulfonamide, DB-053437, 5-Acetamido-1,3,4-thiadiazol-2-sulfonamide, AB00051906, CS-0694998, EU-0100039, NS00008947, 1,4-Thiadiazole-2-sulfonamide, 5-acetamido-, CARBONIC ANHYDRASE INHIBITOR NO 6063, C06805, D00218, D88526, EN300-119493, AB00051906_15, A832415, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanamide, Q413690, Q-200579, Q-200580, SR-01000000065-2, SR-01000000065-4, SR-01000000065-6, 1,3,4-THIADIAZOLE-2-SULFONAMIDE, 5-ACETAMIDO, 2-ACETAMIDO-1,3,4-THIADIAZOLE-5-SULFONAMIDE, BRD-K43457670-001-22-9, BRD-K43457670-001-26-0, Z277559108, (1z)-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanimidic acid, Acetazolamide, European Pharmacopoeia (EP) Reference Standard, Acetazolamide, United States Pharmacopeia (USP) Reference Standard, Acetazolamide for system suitability, European Pharmacopoeia (EP) Reference Standard, Acetazolamide, Pharmaceutical Secondary Standard; Certified Reference Material, 124442-28-0, 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide;N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide;N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, InChI=1/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Drug Type	Small molecule
Formula	C₄H₆N₄O₃S₂
SMILES	CC(=O)NC1=NN=C(S1)S(=O)(=O)N
InChI	1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
InChIKey	BZKPWHYZMXOIDC-UHFFFAOYSA-N
CAS Number	59-66-5
ChEMBL ID	CHEMBL20
ChEBI ID	CHEBI:27690
TTD ID	D0E1SW
Drug Bank ID	DB00819
KEGG ID	C06805
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Sulforaphane, Acetazolamide
Partner Name	Sulforaphane
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Gene Regulation	Down-regulation	Expression	NANOGNB	hsa360030
	Down-regulation	Expression	POU5F1	hsa5460
	Down-regulation	Expression	SOX2	hsa6657
In Vitro Model	NCI-H727	Lung carcinoid tumor	Homo sapiens (Human)	CVCL_1584
In Vitro Model	NCI-H720	Lung carcinoid tumor	Homo sapiens (Human)	CVCL_1583
In Vivo Model	H727 and H720 parental and 3rd generation spheroid cells (3×10⁴) were injected into the subcutaneous inguinal fat pad of NOD/SCID mice.
Result	Human bronchial carcinoid tumor cells serially passaged as spheroids contain a higher fraction of TIC exhibiting a stemness phenotype. This TIC population can be effectively targeted by the combination of AZ + SFN. Our work portends clinical relevance and supports the therapeutic use of the novel AZ+ SFN combination that may target the TIC population of bronchial carcinoids.