| Pair Name | Shikonin, Cisplatin | ||
| Phytochemical Name | Shikonin (PubChem CID: 479503 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Shikonin, Cisplatin | |||
| Disease Info | [ICD-11: 2C94] | Bladder cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation; Induction--> Loss of mitochondrial membrane potential | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 | |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| NCM460 | Healthy | Homo sapiens (Human) | CVCL_0460 | |
| In Vivo Model | HCT116 cells (5×10⁶ cells in 100uL of PBS) were harvested and injected subcutaneously into the right flank of five-week-old athymic BALB/cA nu/nu female mice | |||
| Result | Shikonin as a synergistic agent to cisplatin could be a highly efficient way to achieve anticancer synergism by inducing intracellular oxidative stress | |||
| Pair Name | Shikonin, Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->Ferroptosis | |||
| Gene Regulation | Down-regulation | Expression | GPX4 | hsa2879 |
| Up-regulation | Expression | HMOX1 | hsa3162 | |
| In Vitro Model | A2780/CDDP | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_D619 |
| In Vivo Model | A total of 4×10⁶ A2780/DDP cells were suspended in 200 μl of PBS and injected subcutaneously into the right flank of each mouse. | |||
| Result | Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo. Biochem Biophys Res Commun. 2016 Jan 22;469(4):1075-82. doi: 10.1016/j.bbrc.2015.12.100. | Click |
| 2 | Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation. Phytomedicine. 2023 Apr;112:154701. doi: 10.1016/j.phymed.2023.154701. | Click |
