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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name TRAIL
Drug Type Not Available
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 841
Ref_1
Pair Name Embelin, TRAIL
Partner Name Embelin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->ROS generation
Gene Regulation Down-regulation Expression MAPK3 hsa5595
Down-regulation Expression SOD1 hsa6647
Down-regulation Expression XIAP hsa331
In Vitro Model SUM149PT Breast inflammatory carcinoma Homo sapiens (Human) CVCL_3422
Result Embelin primes IBC cells for TRAIL-mediated apoptosis by its direct action on the anti-caspase activity of XIAP and by shifting the cellular redox balance toward oxidative stress–mediated apoptosis
03. Reference
No. Title Href
1 XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. Mol Cancer Ther. 2012;11(7):1518-1527. doi:10.1158/1535-7163.MCT-11-0787 Click
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