
| Pair Name | Rosmarinic acid, Anti-MUC1 antibody | ||
| Phytochemical Name | Rosmarinic acid (PubChem CID: 5281792 ) | ||
| Anticancer drug Name | Anti-MUC1 antibody (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Rosmarinic acid, Anti-MUC1 antibody | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | MUC1 | hsa4582 |
| Down-regulation | Expression | LGALS3 | hsa3958 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
| Result | Results of the study indicate that combined action of anti-MUC1 and RA is more effective than monotherapy in relation to examined cancer related factors. Such treatment can be considered as new, promising strategy in gastric cancer therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells. Eur J Pharmacol. 2021 Jul 5;902:174119. doi: 10.1016/j.ejphar.2021.174119. | Click |