| Pair Name | Protocatechualdehyde, Dacarbazine | ||
| Phytochemical Name | Protocatechualdehyde (PubChem CID: 8768 ) | ||
| Anticancer drug Name | Dacarbazine (PubChem CID: 135398738 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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| Pair Name | Protocatechualdehyde, Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | MGMT | hsa4255 |
| Up-regulation | Expression | H2AX | hsa3014 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| In Vitro Model | A-375 | Amelanotic melanoma | Homo sapiens (Human) | CVCL_0132 |
| SK-MEL-28 | Cutaneous melanoma | Homo sapiens (Human) | CVCL_0526 | |
| Result | Our study demonstrates that the bioactive compound, Protocatechuic aldehyde, synergistically promotes the cytotoxicity of DTIC to melanoma cells through destabilization of MGMT protein. It could be a potential candidate for melanoma chemotherapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells. BMC Complement Med Ther. 2023 Apr 27;23(1):133. doi: 10.1186/s12906-023-03965-2. | Click |
