Pair Name	Plumbagin, Celecoxib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	STAT3	hsa6774
In Vitro Model	UACC-903	Cutaneous melanoma	Homo sapiens (Human)	CVCL_4052
	Mel JuSo	Cutaneous melanoma	Homo sapiens (Human)	CVCL_1403
	A375-M	Amelanotic melanoma	Homo sapiens (Human)	CVCL_B222
	1205Lu	Cutaneous melanoma	Homo sapiens (Human)	CVCL_5239
In Vivo Model	Subcutaneous injection of 1.0×10⁶ UACC 903 or 1205 Lu melanoma cells were injected above both the left and right rib cages of 4-5 week-old female Athymic-Foxn1nu nude mice
Result	Combination of Celecoxib and Plumbagin decreased melanoma cell proliferation and retarded vascular development of tumors mediated by inhibition of COX-2 and STAT3 leading to decreased levels of key cyclins key on which melanoma cell were dependent for survival.