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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Noscapine, Paclitaxel
Phytochemical Name Noscapine (PubChem CID: 275196 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 608
Ref_1
Pair Name Noscapine, Paclitaxel
Disease Info [ICD-11: 2C82.0] Prostate cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Up-regulation Expression BAX hsa581
Down-regulation Expression AR hsa367
Down-regulation Expression KLK3 hsa354
In Vitro Model LNCaP Prostate carcinoma Homo sapiens (Human) CVCL_0395
PC-3 Prostate carcinoma Homo sapiens (Human) CVCL_0035
Result This study provides a novel concept of combination treatment of paclitaxel and noscapine to improve efficiency in human prostate cancer treatment.
03. Reference
No. Title Href
1 Synergistic Anticancer Effect of Paclitaxel and Noscapine on Human Prostate Cancer Cell Lines. Iran J Pharm Res. 2017 Fall;16(4):1432-1442. Click
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