| Pair Name | Niacinamide, Gemcitabine | ||
| Phytochemical Name | Niacinamide (PubChem CID: 936 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Niacinamide, Gemcitabine | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Up-regulation | Expression | CCL21 | hsa6366 |
| Down-regulation | Expression | HABP2 | hsa3026 | |
| Up-regulation | Expression | PECAM1 | hsa5175 | |
| In Vitro Model | Panc02 | Mouse pancreatic ductal adenocarcinoma | Mus musculus (Mouse) | CVCL_D627 |
| In Vivo Model | The spleen/pancreas was gently retracted and positioned to allow injection of Panc-02 tumor cells (1×10⁶/50 µL phosphate-buffered saline (PBS)) directly into the pancreas, from the tail all the way to the head of the pancreas. | |||
| Result | This study highlights the potential of NAM+GEM as immunotherapy for advanced pancreatic cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice. J Immunother Cancer. 2020 Nov;8(2):e001250. doi: 10.1136/jitc-2020-001250. | Click |
