Pair Name	Maslinic acid, Gemcitabine
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Activity	NFKB1	hsa4790
In Vitro Model	EH-GB1	Gallbladder carcinoma	Homo sapiens (Human)	CVCL_IU73
	EH-GB2	Gallbladder carcinoma	Homo sapiens (Human)	CVCL_6899
	GBC-SD	Gallbladder carcinoma	Homo sapiens (Human)	CVCL_6903
In Vivo Model	EH-GB2 tumor cells were subcutaneously injected into the mice (2×10⁶ cells/mouse).
Result	The results suggest that MA potentiates the antitumor effects of GEM in human GBC cell lines by suppressing the activation of NF-κB and its dowstream gene products, which are involved in survival signaling.