| Pair Name | Leonurine, Cisplatin | ||
| Phytochemical Name | Leonurine (PubChem CID: 161464 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Leonurine, Cisplatin | |||
| Disease Info | [ICD-11: 2C77.Z] | Cervical cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | PARP1 | hsa142 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | MDM4 | hsa4194 | |
| Down-regulation | Expression | ABCC1 | hsa4363 | |
| Down-regulation | Expression | ABCB1 | hsa5243 | |
| In Vitro Model | C-33 A | Human papillomavirus-independent cervical squamous cell carcinoma | Homo sapiens (Human) | CVCL_1094 |
| MS751 | Human papillomavirus-related cervical squamous cell carcinoma | Homo sapiens (Human) | CVCL_4996 | |
| Result | Leonurine and cisplatin have synergistic antitumorigenic effects on cervical cancer. Combination with leonurine may serve as a novel strategy for enhancing cisplatin sensitivity via the inhibition of the expression of MRP1 and P-Gp. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins. Drug Des Devel Ther. 2020 May 15;14:1885-1895. doi: 10.2147/DDDT.S252112. | Click |
