| Pair Name | Kaempferol, Gefitinib | ||
| Phytochemical Name | Kaempferol (PubChem CID: 5280863 ) | ||
| Anticancer drug Name | Gefitinib (PubChem CID: 123631 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Kaempferol, Gefitinib | |||
| Disease Info | [ICD-11: 2F7Z] | Glioma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | EGFR | hsa1956 |
| Down-regulation | Phosphorylation | SRC | hsa6714 | |
| Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
| In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
| In Vivo Model | U251 cells at a count of 1×10⁷cells per 200 μl weresubcutaneously injected into the right armpit and mice wererandomly divided into six groups of six each. | |||
| Result | Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway | |||
| No. | Title | Href |
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| 1 | Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway. Drug Dev Res. 2023 May;84(3):592-610. doi: 10.1002/ddr.22048. | Click |
