Pair Name	Honokiol, Fluorouracil
Disease Info	[ICD-11: 2B62.0]	Tongue squamous cell carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	EGFR	hsa1956
In Vitro Model	HSC-3	Tongue squamous cell carcinoma	Homo sapiens (Human)	CVCL_1288
	HSC-4	Tongue squamous cell carcinoma	Homo sapiens (Human)	CVCL_1289
In Vivo Model	A total of 2×10⁶ HSC-3 cells were suspended in 100 uL serum-free DMEM and injected subcutaneously into the right flank of BALB/c nude mice to establish OSCC xenograft models
Result	These findings suggest that HNK and 5-FU exert a synergistic therapeutic effect on OSCC by inducing apoptosis. HNK might thus enhance the clinical therapeutic efficacy of 5-FU without increasing its toxicity.