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4-hydroxycinnamoyl(feroyl)methane, curcumin II, demethoxy-curcumin, demethoxycurcumin, monodemethoxycurcumin

No.	Title	Href
1	Demethoxycurcumin increases the sensitivity of cisplatin-resistant non-small lung cancer cells to cisplatin and induces apoptosis by activating the caspase signaling pathway. Oncol Lett. 2020 Nov;20(5):209. doi: 10.3892/ol.2020.12072.	`Click`
2	Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells. J Cancer Res Clin Oncol. 2020 Jan;146(1):117-126. doi: 10.1007/s00432-019-03107-7.	`Click`

No.

Title

Href

Demethoxycurcumin increases the sensitivity of cisplatin-resistant non-small lung cancer cells to cisplatin and induces apoptosis by activating the caspase signaling pathway. Oncol Lett. 2020 Nov;20(5):209. doi: 10.3892/ol.2020.12072.

Click

Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells. J Cancer Res Clin Oncol. 2020 Jan;146(1):117-126. doi: 10.1007/s00432-019-03107-7.

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Name	Demethoxycurcumin
PubChem CID	5469424
Molecular Weight	338.4g/mol
Synonyms	4-hydroxycinnamoyl(feroyl)methane, curcumin II, demethoxy-curcumin, demethoxycurcumin, monodemethoxycurcumin
Formula	C₂₀H₁₈O₅
SMILES	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
InChI	1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+
InChIKey	HJTVQHVGMGKONQ-LUZURFALSA-N
CAS Number	22608-11-3
ChEMBL ID	CHEMBL105360
ChEBI ID	CHEBI:65737
Herb ID	HBIN023227
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	BiBa
Use Part	Near Ripe Or Ripe Fruit Spike
Habitat	YunNan, GuangDong
Flavor	Pungent
Meridian Tropism	Stomach, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Piperales 　　　　-->Family: Piperaceae 　　　　　-->Genus: Piper 　　　　　　-->Species: Piper longum

Chineses Pinyin	JiangHuang
Use Part	Tuberoid
Habitat	SiChuan, FuJian, GuangDong, ZheJiang, JiangXi
Flavor	Pungent; Bitter
Meridian Tropism	Spleen; Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Curcuma 　　　　　　-->Species: Curcuma longa

Pair Name	Demethoxycurcumin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	For a xenograft model, A549/DDP cells were injected into the inguinal mammary fat pad of Balb/c congenic athymic nude mice.
Result	The findings from the present study suggested that DMC in combination with DDP may be considered as a novel combination regimen for restoring DDP sensitivity in DDP-resistant NSCLC cells.

Pair Name	Demethoxycurcumin, AT101
Partner Name	AT101
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Gene Regulation	Up-regulation	Phosphorylation	AKT1	hsa207
In Vitro Model	PC-1 [Human pancreatic carcinoma]	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_S969
	PC-2 [Human pancreatic carcinoma Germany]	Pancreatic carcinoma	Homo sapiens (Human)	CVCL_C1YF
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
Result	Combined treatment with different drugs might be an option to efficiently overcome chemoresistance of GBM cells in a long-term treatment strategy.