Pair Name	Curcumol, TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	NQO2	hsa4835
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
	NCI-H1975	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1511
	NCI-H358	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1559
	NCI-H460	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0459
In Vivo Model	BALB/c nude mice (5-week-old) were subcutaneously inoculated with A549 cells (1×10⁶)
Result	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.