| Pair Name | Curcumin, Fluorouracil | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Fluorouracil |
| Adverse Reactions | Application site erythema, application site pruritus. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Pueraria thomsonii; Bupleurum scorzonerifolium; Pueraria thomsonii; Pueraria edulis |
| Reference | Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019. ref_link |
| Pair Name | Curcumin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | MAPK1 | hsa5594 |
| Down-regulation | Phosphorylation | STAT1 | hsa6772 | |
| Down-regulation | Expression | L1CAM | hsa3897 | |
| In Vitro Model | SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 |
| In Vivo Model | SW620 cells (5×10⁶/0.1 ml Matrigel, Sigma-Aldrich) were injected subcutaneously into the lower right flank of female nude mice. | |||
| Result | We conclude that curcumin promotes chemosensitivity of CRC cells to 5-FU by downregulating L1 expression. Our findings provide experimental evidence for the synergism between curcumin and 5-FU, which can be utilized in clinical applications for reducing the toxicity and adverse effects of 5-FU. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer. Phytomedicine. 2021 May;85:153547. doi: 10.1016/j.phymed.2021.153547. | Click |
