corylin
| Name | Corylin | ||
| PubChem CID | 5316097 | ||
| Molecular Weight | 320.3g/mol | ||
| Synonyms |
corylin |
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| Formula | C₂₀H₁₆O₄ | ||
| SMILES | CC1(C=CC2=C(O1)C=CC(=C2)C3=COC4=C(C3=O)C=CC(=C4)O)C | ||
| InChI | 1S/C20H16O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)16-11-23-18-10-14(21)4-5-15(18)19(16)22/h3-11,21H,1-2H3 | ||
| InChIKey | PWAACAMQKVIVPZ-UHFFFAOYSA-N | ||
| CAS Number | 53947-92-5 | ||
| ChEMBL ID | CHEMBL1271888 | ||
| Herb ID | HBIN021561 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | BuGuZhi | ||
| Use Part | Fruit | ||
| Habitat | HeNan, SiChuan, AnHui | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Kidney, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Psoralea
-->Species: Psoralea corylifolia
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| Pair Name | Corylin, Etoposide | |||
| Partner Name | Etoposide | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Down-regulation | Expression | RAD51 | hsa5888 | |
| In Vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 |
| Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 | |
| In Vivo Model | A total of 4×10⁶ Huh7 cells were resuspended in 100 μl of saline with 50% Matrigel, and the suspensions were subcutaneously implanted into the left and right flank regions of the mice. | |||
| Result | Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair | |||
