Pair Name | Carnosic acid, Cisplatin | ||
Phytochemical Name | Carnosic acid (PubChem CID: 65126 ) | ||
Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Carnosic acid, Cisplatin | |||
Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
Gene Regulation | Down-regulation | Expression | ARG1 | hsa383 |
Up-regulation | Expression | CD8A | hsa925 | |
Up-regulation | Expression | FASLG | hsa356 | |
Up-regulation | Expression | GZMB | hsa3002 | |
Up-regulation | Expression | IFNG | hsa3458 | |
Down-regulation | Expression | MMP9 | hsa4318 | |
Up-regulation | Expression | PRF1 | hsa5551 | |
In Vitro Model | A9 [Mouse Lewis lung carcinoma] | Malignant tumors of the mouse pulmonary system | Mus musculus (Mouse) | CVCL_S007 |
In Vivo Model | Mouse LLC (Lewis lung cancer) cells (5×10⁶ cells in 0.1 mL) were injected into the right flank of C57BL/6 mice. | |||
Result | Our study proved that the functional suppression of MDSC by carnosic acid promoted the lethality of CD8 T cells, which contributed to the enhancement of anti-lung cancer effect of cisplatin. |
No. | Title | Href |
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1 | Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells. Chin J Nat Med. 2018 Dec;16(12):907-915. doi: 10.1016/S1875-5364(18)30132-8. | Click |