7,3'-dihydroxy-4'-methoxyisoflavone, calycosin
| Name | Calycosin-7-O-β-D-glucoside | ||
| PubChem CID | 5280448 | ||
| Molecular Weight | 284.26g/mol | ||
| Synonyms |
7,3'-dihydroxy-4'-methoxyisoflavone, calycosin |
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| Formula | C₁₆H₁₂O₅ | ||
| SMILES | COC1=C(C=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O | ||
| InChI | 1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3 | ||
| InChIKey | ZZAJQOPSWWVMBI-UHFFFAOYSA-N | ||
| CAS Number | 20575-57-9 | ||
| ChEMBL ID | CHEMBL241608 | ||
| ChEBI ID | CHEBI:17793 | ||
| Herb ID | None | ||
| KEGG ID | C01562 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | MengGuHuangQi | ||
| Use Part | Root | ||
| Habitat | HeiLongJiang, JiLin, NeiMengGu, HeBei, ShanXi, XiZang | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Magnoliopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Astragalus
-->Species: Astragalus membranaceus
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| Pair Name | Calycosin-7-O-β-D-glucoside, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | SK-OV-3 | Ovarian serous cystadenocarcinoma | Homo sapiens (Human) | CVCL_0532 |
| Result | CG significantly increases the CDDP-induced apoptosis of the SK-OV-3 cells through the p53 pathway at the cellular level. In addition, using the drugs in combination reduces the toxicity and side effects caused by using CDDP alone. | |||
