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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Brusatol, Cabergoline
Phytochemical Name Brusatol (PubChem CID: 73432 )
Anticancer drug Name Cabergoline (PubChem CID: 54746 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 179
Ref_1
Pair Name Brusatol, Cabergoline
Disease Info [ICD-11: 2F37] Pituitary adenomas Investigative
Biological Phenomena Induction-->ROS accumulation
Gene Regulation Down-regulation Phosphorylation EIF4EBP1 hsa1978
Down-regulation Expression RHEB hsa6009
Up-regulation Expression ROS1 hsa6098
Down-regulation Phosphorylation RPS6KB1 hsa6198
In Vitro Model GH3 Rat pituitary gland neoplasm Rattus norvegicus (Rat) CVCL_0273
MMQ Rat pituitary gland neoplasm Rattus norvegicus (Rat) CVCL_2117
In Vivo Model A total of 5×10⁶ of the indicated MMQ and GH3 cells were resuspended in 100 μL PBS buffer mixed with Matrigel (1 : 1) and then subcutaneously injected into the back of each nude mice.
Result Combined use of CAB and BT may increase the clinical effectiveness of treatment for human pituitary adenomas.
03. Reference
No. Title Href
1 Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas. Oxid Med Cell Longev. 2021 Jun 16;2021:6696015. doi: 10.1155/2021/6696015. Click
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