| Pair Name | Baicalein, Doxorubicin | ||
| Phytochemical Name | Baicalein (PubChem CID: 5281605 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Baicalein, Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Down-regulation | Expression | CDK1 | hsa983 |
| Down-regulation | Phosphorylation | DNM1L | hsa10059 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | PINK1 | hsa65018 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1 | |||
| No. | Title | Href |
|---|---|---|
| 1 | Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1. Mol Cell Biochem. 2023 Jul;478(7):1519-1531. doi: 10.1007/s11010-022-04597-9. | Click |
