Pair Name	Triptolide, ABT-199
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BBC3	hsa27113
	Up-regulation	Expression	BCL2L11	KEGG ID N.A.
	Up-regulation	Expression	BID	hsa637
	Up-regulation	Expression	PMAIP1	hsa5366
In Vitro Model	MV4-11	Childhood acute monocytic leukemia	Homo sapiens (Human)	CVCL_0064
	MOLM-13	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_2119
	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
	THP-1	Childhood acute monocytic leukemia	Homo sapiens (Human)	CVCL_0006
	KG-1a	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1824
In Vivo Model	5-6 week-old female BALB/C nude mice (18–20 g; Beijing HFK bioscience Co. Ltd.) were injected subcutaneously with 5.8×10⁶ MOLM-13 cells at the right flank of mice.
Result	These findings suggest that the regimen combining TPL and ABT-199 might be active against AML by inducing robust apoptosis through reciprocal regulation of anti- and proapoptotic Bcl-2 family proteins, therefore providing a strong rationale for the clinical investigation of this combination regimen for the treatment of AML.