Pair Name	Tanshinone IIA, Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	PIK3CA	hsa5290
	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CASP3	hsa836
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	Equal numbers of A549 cells (2×10⁶ cells) were resuspended in 100 ml of normal saline and subcutaneously injected into unilateral axillary fossae of 4-week-old nude mice (BALB/c-nu).
Result	The combination of Tan IIA and cisplatin exhibited the most significant difference. Tanshinone IIA may function as a novel option for combination therapy for non-small-cell lung cancer treatment.