| Pair Name | Sulforaphane, PR-104A | ||
| Phytochemical Name | Sulforaphane (PubChem CID: 5350 ) | ||
| Anticancer drug Name | PR-104A (PubChem CID: 9848786 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Sulforaphane, PR-104A | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | AKR1C3 | hsa8644 |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| Result | The enhanced response of PR-104A after preconditioning with SF was apparent only in cancer cells provided that AKR1C3 is expressed, while its expression in non-cancerous cells did not elicit such a response. Therefore, a subset of cancers may be susceptible to combined food-derived component and prodrug treatments with no harm to normal tissues. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. PLoS One. 2016 Mar 7;11(3):e0150219. doi: 10.1371/journal.pone.0150219. | Click |
