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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sulforaphane, PR-104A
Phytochemical Name Sulforaphane (PubChem CID: 5350 )
Anticancer drug Name PR-104A (PubChem CID: 9848786 )
Structure of
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Structure of
Anticancer Drug		 2D-img
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 555
Ref_1
Pair Name Sulforaphane, PR-104A
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Gene Regulation Up-regulation Expression AKR1C3 hsa8644
In Vitro Model HT-29 Colon adenocarcinoma Homo sapiens (Human) CVCL_0320
SW620 Colon adenocarcinoma Homo sapiens (Human) CVCL_0547
Result The enhanced response of PR-104A after preconditioning with SF was apparent only in cancer cells provided that AKR1C3 is expressed, while its expression in non-cancerous cells did not elicit such a response. Therefore, a subset of cancers may be susceptible to combined food-derived component and prodrug treatments with no harm to normal tissues.
03. Reference
No. Title Href
1 Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. PLoS One. 2016 Mar 7;11(3):e0150219. doi: 10.1371/journal.pone.0150219. Click
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