InterPAD - DETAILS

PR-104A, 680199-06-8, PR 104A, SN 27858, 2-((2-Bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4,6-dinitrophenyl)amino)ethyl methanesulfonate, 2-[N-(2-bromoethyl)-2-(2-hydroxyethylcarbamoyl)-4,6-dinitroanilino]ethyl methanesulfonate, 3,5-Dinitrobenzamide nitrogen mustard, 397986RF9L, 2-((2-Bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-N-(2-hydroxyethyl)-3,5-dinitrobenzamide, 2-((2-bromoethyl)-2-{[(2-hydroxyethyl)amino]carbonyl}-4,6-dinitroanilino)ethyl methanesulfonate, 2-(N-(2-Bromoethyl)-2-(((2-hydroxyethyl)amino)carbonyl)-4,6-dinitroanilino)ethyl methanesulfonate, Benzamide, 2-((2-bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-N-(2-hydroxyethyl)-3,5-dinitro-, SCHEMBL366334, CHEMBL4438907, UNII-397986RF9L, AZICEEZSDKZDHX-UHFFFAOYSA-N, AKOS025147034, AKOS040749231, HY-14572, MS-29270, CS-0003452, G14034, J-505203, 2-((2-Bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4,6-dinitrophenyl)amino)ethylmethanesulfonate

No.	Title	Href
1	Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. PLoS One. 2016 Mar 7;11(3):e0150219. doi: 10.1371/journal.pone.0150219.	`Click`

No.

Title

Href

Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. PLoS One. 2016 Mar 7;11(3):e0150219. doi: 10.1371/journal.pone.0150219.

Click

Name	PR-104A
PubChem CID	9848786
Molecular Weight	499.29g/mol
Synonyms	PR-104A, 680199-06-8, PR 104A, SN 27858, 2-((2-Bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4,6-dinitrophenyl)amino)ethyl methanesulfonate, 2-[N-(2-bromoethyl)-2-(2-hydroxyethylcarbamoyl)-4,6-dinitroanilino]ethyl methanesulfonate, 3,5-Dinitrobenzamide nitrogen mustard, 397986RF9L, 2-((2-Bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-N-(2-hydroxyethyl)-3,5-dinitrobenzamide, 2-((2-bromoethyl)-2-{[(2-hydroxyethyl)amino]carbonyl}-4,6-dinitroanilino)ethyl methanesulfonate, 2-(N-(2-Bromoethyl)-2-(((2-hydroxyethyl)amino)carbonyl)-4,6-dinitroanilino)ethyl methanesulfonate, Benzamide, 2-((2-bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-N-(2-hydroxyethyl)-3,5-dinitro-, SCHEMBL366334, CHEMBL4438907, UNII-397986RF9L, AZICEEZSDKZDHX-UHFFFAOYSA-N, AKOS025147034, AKOS040749231, HY-14572, MS-29270, CS-0003452, G14034, J-505203, 2-((2-Bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4,6-dinitrophenyl)amino)ethylmethanesulfonate
Drug Type	Small molecule
Formula	C₁₄H₁₉BrN₄O₉S
SMILES	CS(=O)(=O)OCCN(CCBr)C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])C(=O)NCCO
InChI	1S/C14H19BrN4O9S/c1-29(26,27)28-7-5-17(4-2-15)13-11(14(21)16-3-6-20)8-10(18(22)23)9-12(13)19(24)25/h8-9,20H,2-7H2,1H3,(H,16,21)
InChIKey	AZICEEZSDKZDHX-UHFFFAOYSA-N
CAS Number	680199-06-8
ChEMBL ID	CHEMBL4438907
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Sulforaphane, PR-104A
Partner Name	Sulforaphane
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Gene Regulation	Up-regulation	Expression	AKR1C3	hsa8644
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
In Vitro Model	SW620	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0547
Result	The enhanced response of PR-104A after preconditioning with SF was apparent only in cancer cells provided that AKR1C3 is expressed, while its expression in non-cancerous cells did not elicit such a response. Therefore, a subset of cancers may be susceptible to combined food-derived component and prodrug treatments with no harm to normal tissues.