| Name | Aldo-keto reductase family 1 member C3 | ||
| UniProt ID | AK1C3_HUMAN | ||
| Gene Name | AKR1C3 | ||
| Gene ID | 8644 | ||
| Synonyms |
AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
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| Sequence |
MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD RNLHYFNSDSFASHPNYPYSDEY |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa8644 | ||
| TTD ID | T60857 | ||
| Pfam | PF00248 | ||
| Pair Name | Sulforaphane, PR-104A | |||
| Phytochemical | Sulforaphane | |||
| Drug | PR-104A | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Regulate Info | Up-regulation | Aldo-keto reductase family 1 member C3 | Expression | |
| Result | The enhanced response of PR-104A after preconditioning with SF was apparent only in cancer cells provided that AKR1C3 is expressed, while its expression in non-cancerous cells did not elicit such a response. Therefore, a subset of cancers may be susceptible to combined food-derived component and prodrug treatments with no harm to normal tissues. | |||
