| Pair Name | Sulforaphane, Fernblock® XP | ||
| Phytochemical Name | Sulforaphane (PubChem CID: 5350 ) | ||
| Anticancer drug Name | Fernblock® XP (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Sulforaphane, Fernblock® XP | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | IL1B | hsa3553 |
| Down-regulation | Expression | MMP1 | hsa4312 | |
| Down-regulation | Expression | MMP3 | hsa4314 | |
| In Vitro Model | WM115 | Melanoma | Homo sapiens (Human) | CVCL_0040 |
| WM266-4 | Melanoma | Homo sapiens (Human) | CVCL_2765 | |
| Result | SFN/FB was more efficient than SFN or FB alone in inhibiting MMP-1 and -3 production and IL-1β secretion in the presence of a pro-inflammatory stimulus such as TNF-α. The potential use of SFN/FB based supplements for the prevention of skin aging and as adjuvants in the treatment of advanced melanoma is suggested. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The Combination of Sulforaphane and Fernblock® XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines. Nutrients. 2020 May 30;12(6):1608. doi: 10.3390/nu12061608. | Click |
