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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Solamargine, Bortezomib
Phytochemical Name Solamargine (PubChem CID: 73611 )
Anticancer drug Name Bortezomib (PubChem CID: 387447 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 45
Ref_1
Pair Name Solamargine, Bortezomib
Disease Info [ICD-11: 2A83] Multiple myeloma Investigative
Biological Phenomena Induction-->Autophagy
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression BECN1 hsa8678
Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression MAP1LC3A hsa84557
Up-regulation Expression MAP1LC3B hsa81631
In Vitro Model ARP-1 Plasma cell myeloma Homo sapiens (Human) CVCL_D523
NCI-H929 Plasma cell myeloma Homo sapiens (Human) CVCL_1600
Result These findings indicate that SM exerts an anti-MM effect, at least in part, by activating cell autophagy and reveal that SM alone or in combination with BTZ is a potential therapeutic strategy for treating MM.
03. Reference
No. Title Href
1 Solamargine induces autophagy-mediated apoptosis and enhances bortezomib activity in multiple myeloma. Clin Exp Pharmacol Physiol. 2022 Jun;49(6):674-685. doi: 10.1111/1440-1681.13643. Click
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