| Pair Name | Rhein, Pemetrexed | ||
| Phytochemical Name | Rhein (PubChem CID: 10168 ) | ||
| Anticancer drug Name | Pemetrexed (PubChem CID: 135410875 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Rhein, Pemetrexed | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Down-regulation | Expression | MTOR | hsa2475 | |
| Down-regulation | Expression | PIK3CA | hsa5290 | |
| Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | Our findings demonstrated that the potential application of rhein as a candidate drug in combination with PTX is promising for treatment of the human lung cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein. J Cell Physiol. 2020 Apr;235(4):3309-3319. doi: 10.1002/jcp.29218. | Click |
