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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Pterostilbene, Osimertinib
Phytochemical Name Pterostilbene (PubChem CID: 5281727 )
Anticancer drug Name Osimertinib (PubChem CID: 71496458 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 801
Ref_1
Pair Name Pterostilbene, Osimertinib
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Gene Regulation Down-regulation Phosphorylation CDCP1 hsa64866
Down-regulation Phosphorylation STAT3 hsa6774
Down-regulation Phosphorylation YAP1 hsa10413
In Vitro Model MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
PC-9 Lung adenocarcinoma Homo sapiens (Human) CVCL_B260
NCI-H1975 Lung adenocarcinoma Homo sapiens (Human) CVCL_1511
Result The results of this study indicate that pterostilbene may be used to abrogate the activated resistance pathways of single osimertinib treatment in EGFR-mutation positive NSCLC. Future studies should focus on in vivo translation and confirmation of these results.
03. Reference
No. Title Href
1 Osimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC). Int J Biol Sci. 2019 Sep 7;15(12):2607-2614. doi: 10.7150/ijbs.32889. Click
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