Pair Name	Polydatin, Brusatol
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Gene Regulation	Down-regulation	Expression	HMOX1	hsa3162
	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	NQO1	hsa1728
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	SUM159PT	Breast pleomorphic carcinoma	Homo sapiens (Human)	CVCL_5423
In Vivo Model	MDA-MB-231 (100 μL containing 5×10⁶ cells) were injected subcutaneously into nude mice. Until the tumor volume reached 100–200 mm3, mice in the individual administration groups were injected intraperitoneally with PD 50 mg/kg, the combined administration group was PD 25 mg/kg and BRU 1 mg/kg.
Result	We could significantly reduce tumor cell growth while avoiding toxic side effects, providing a treatment method with greater clinical application value for TNBC treatment.