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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Piperlongumine, Cisplatin
Phytochemical Name Piperlongumine (PubChem CID: 637858 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 11
Ref_1
Pair Name Piperlongumine, Cisplatin
Disease Info [ICD-11: 2C94.Z] Bladder cancer Investigative
Biological Phenomena Induction-->ROS accumulation
Gene Regulation Up-regulation Activity RIPK1 hsa8737
Up-regulation Phosphorylation RIPK3 hsa11035
Up-regulation Phosphorylation MLKL hsa197259
Up-regulation Phosphorylation DNM1L hsa10059
In Vitro Model T24 Bladder carcinoma Homo sapiens (Human) CVCL_0554
Result Our results demonstrated the role of RIPK1 in cisplatin-resistant cells and the sensitization effect of the natural drug PL on bladder cancer. These may provide a new treatment strategy for overcoming cisplatin resistance in bladder cancer.
03. Reference
No. Title Href
1 Piperlongumine increases the sensitivity of bladder cancer to cisplatin by mitochondrial ROS. J Clin Lab Anal. 2022 Jun;36(6):e24452. doi: 10.1002/jcla.24452. Click
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