panaxadiol, panaxadiol, (3beta,12beta)-isomer
| Name | Panaxadiol | ||
| PubChem CID | 73498 | ||
| Molecular Weight | 460.7g/mol | ||
| Synonyms |
panaxadiol, panaxadiol, (3beta,12beta)-isomer |
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| Formula | C₃₀H₅₂O₃ | ||
| SMILES | CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C | ||
| InChI | 1S/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3/t19-,20+,21-,22+,23-,24-,27-,28+,29+,30+/m0/s1 | ||
| InChIKey | PVLHOJXLNBFHDX-XHJPDDKBSA-N | ||
| CAS Number | 19666-76-3 | ||
| ChEMBL ID | CHEMBL491655 | ||
| ChEBI ID | CHEBI:192043 | ||
| Herb ID | HBIN038739 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | JiaoGuLan | ||
| Use Part | Whole Grass | ||
| Habitat | SiChuan, YunNan, HuBei, HuNan, GuangDong, GuangXi, Shaanxi, FuJian | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung, Spleen, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Cucurbitales
-->Family: Cucurbitaceae
-->Genus: Gynostemma
-->Species: Gynostemma pentaphyllum
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| Chineses Pinyin | SanQi | ||
| Use Part | Root | ||
| Habitat | YunNan, GuangXi | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Liver, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax notoginseng
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| Chineses Pinyin | SanQiHua | ||
| Use Part | Flower | ||
| Habitat | JiangXi, HuBei, GuangDong, GuangXi, SiChuan, YunNan | ||
| Flavor | Sweet | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax notoginseng
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| Chineses Pinyin | JiaRenShen | ||
| Use Part | Leaf, Root, Whole Herb | ||
| Habitat | XiZang, Nepal | ||
| Chineses Pinyin | RenShen | ||
| Use Part | Root | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Spleen, Lung, Heart, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Chineses Pinyin | RenShenLu | ||
| Use Part | Rhizome | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Stomach, Spleen, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Pair Name | Panaxadiol, Irinotecan | |||
| Partner Name | Irinotecan | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Activity | CASP9 | hsa842 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| Result | Data from this study suggested that caspase-3- and caspase-9-mediated apoptosis may play an important role in the panaxadiol enhanced antiproliferative effects of irinotecan on human colorectal cancer cells. | |||
