InterPAD - DETAILS

L-methyl-selenocysteine, methyl selenocysteine, methylselenocysteine, Se-methyl-selenocysteine, Se-methylselenocysteine, selenohomocysteine, selenomethylselenocysteine, selenomethylselenocysteine, (D,L)-isomer, selenomethylselenocysteine, (L)-isomer, selenomethylselenocysteine, (L)-isomer, 75Se-labeled, SeMCys

No.	Title	Href
1	Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis. Breast Cancer Res Treat. 2009 Nov;118(1):33-43. doi: 10.1007/s10549-008-0216-x.	`Click`
2	Methylselenocysteine Potentiates Etoposide-Induced Cytotoxicity by Enhancing Gap Junction Activity. Biol Pharm Bull. 2022;45(4):467-476. doi: 10.1248/bpb.b21-00893.	`Click`

No.

Title

Href

Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis. Breast Cancer Res Treat. 2009 Nov;118(1):33-43. doi: 10.1007/s10549-008-0216-x.

Click

Methylselenocysteine Potentiates Etoposide-Induced Cytotoxicity by Enhancing Gap Junction Activity. Biol Pharm Bull. 2022;45(4):467-476. doi: 10.1248/bpb.b21-00893.

Click

Name	Methylselenocysteine
PubChem CID	147004
Molecular Weight	182.09g/mol
Synonyms	L-methyl-selenocysteine, methyl selenocysteine, methylselenocysteine, Se-methyl-selenocysteine, Se-methylselenocysteine, selenohomocysteine, selenomethylselenocysteine, selenomethylselenocysteine, (D,L)-isomer, selenomethylselenocysteine, (L)-isomer, selenomethylselenocysteine, (L)-isomer, 75Se-labeled, SeMCys
Formula	C₄H₉NO₂Se
SMILES	C[Se]CC(C(=O)O)N
InChI	1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
InChIKey	XDSSPSLGNGIIHP-VKHMYHEASA-N
CAS Number	26046-90-2
ChEMBL ID	CHEMBL62382
ChEBI ID	CHEBI:27812
Herb ID	HBIN035417
Drug Bank ID	DB12697
KEGG ID	C05689
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	RenShenLu
Use Part	Rhizome
Habitat	JiLin, LiaoNing, HeiLongJiang
Flavor	Sweet, Mildly bitter
Meridian Tropism	Stomach, Spleen, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Araliaceae 　　　　　-->Genus: Panax 　　　　　　-->Species: Panax ginseng

Chineses Pinyin	DaSuan
Use Part	Bulb
Habitat	China
Flavor	Pungent
Meridian Tropism	Spleen; Stomach; Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Amaryllidaceae 　　　　　-->Genus: Allium 　　　　　　-->Species: Allium sativum

Pair Name	Methylselenocysteine, Tamoxifen
Partner Name	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	CCND1	hsa595
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vivo Model	About 5×10⁶ cells suspension in 50 uL sterile PBS were mixed with 100 uL Matrigel and administered within both sides of the inguinal mammary fat pad of NU/NU immune-compromised female ovariectomized mice
Result	These findings demonstrate synergistic growth inhibition of ERalpha positive breast cancer xenografts by combination of tamoxifen with organic selenium compounds. Organic selenium may provide added benefit when combined with tamoxifen in adjuvant therapy or prevention.

Pair Name	Methylselenocysteine, Etoposide
Partner Name	Etoposide
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Gap junction activity
Gene Regulation	Up-regulation	Expression	GJB1	hsa2705
Gene Regulation	Up-regulation	Expression	GJB2	hsa2706
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	We provide the novel finding that MSC increases etoposide-mediated cytotoxicity by enhancing GJ activity, due to elevated Cx expression through a GSH-dependent posttranscriptional mechanism. More generally, the study highlights potential benefit of the combination of GJ modulators and chemotherapeutic agents in anticancer treatment.