| Pair Name | Lycorine, Temozolomide | ||
| Phytochemical Name | Lycorine (PubChem CID: 72378 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Lycorine, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Expression | IKBKE | hsa9641 |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| In Vitro Model | C6 | Rat malignant glioma | Rattus norvegicus (Rat) | CVCL_0194 |
| Result | Our study suggested that lycorine exerts an anti-glioma effect by inducing ROS production and inhibiting NF-κB, which validated that lycorine may be a potential candidate for glioma treatment alone or in combination with TMZ. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jun;396(6):1247-1255. doi: 10.1007/s00210-023-02384-x. | Click |
