Pair Name | Kaempferol, Docetaxel | ||
Phytochemical Name | Kaempferol (PubChem CID: 5280863 ) | ||
Anticancer drug Name | Docetaxel (PubChem CID: 148124 ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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Pair Name | Kaempferol, Docetaxel | |||
Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
Biological Phenomena | Induction-->Autophagy | |||
Gene Regulation | Up-regulation | Expression | BECN1 | hsa8678 |
Up-regulation | Expression | GABPA | hsa2551 | |
Down-regulation | Expression | MAP1LC3A | hsa84557 | |
Up-regulation | Expression | MAP1LC3B | hsa81631 | |
Up-regulation | Expression | SQSTM1 | hsa8878 | |
In Vitro Model | DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 |
PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
In Vivo Model | Mouse was subcutaneously inoculated with 5×10⁵ androgen-independent PC-3 human prostate cancer cells | |||
Result | The above cellular and animal data suggest that docetaxel in combination with kaempferol has significant anti-prostate cancer effects and that it works by inducing autophagy in cells. |
No. | Title | Href |
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1 | Combination of Kaempferol and Docetaxel Induces Autophagy in Prostate Cancer Cells In Vitro and In Vivo. Int J Mol Sci. 2023 Sep 25;24(19):14519. doi: 10.3390/ijms241914519. | Click |